A group of friends on holiday on an island experiment with a new designer drug that makes them lose their ability to control their urges.

Some of Sin City's most hard-boiled citizens cross paths with a few of its more reviled inhabitants.

Ex-Federale agent Machete is recruited by the President of the United States for a mission which would be impossible for any mortal man – he must take down a madman revolutionary and an eccentric billionaire arms dealer who has hatched a plan to spread war and anarchy across the planet.

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