Picking up immediately after the events in Resident Evil: Retribution, Alice (Milla Jovovich) is the only survivor of what was meant to be humanity's final stand against the undead.

Set in the Aokigahara Forest, a real-life place in Japan where people go to end their lives. Against this backdrop, a young American woman comes in search of her twin sister, who has mysteriously disappeared.

Britain, A.D. 117. Quintus Dias, the sole survivor of a Pictish raid on a Roman frontier fort, marches north with General Virilus' legendary Ninth Legion, under orders to wipe the Picts from the face of the Earth and destroy their leader, Gorlacon.

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