A parasitic alien soul is injected into the body of Melanie Stryder. Instead of carrying out her race's mission of taking over the Earth, "Wanda" (as she comes to be called) forms a bond with her host and sets out to aid other free humans.

John Carter is a war-weary, former military captain who's inexplicably transported to the mysterious and exotic planet of Barsoom (Mars) and reluctantly becomes embroiled in an epic conflict.

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