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It is 1967, and Larry Gopnik, a physics professor at a quiet Midwestern university, has just been informed by his wife Judith that she is leaving him.
This drama centers on Hank Chinaski, the fictional alter-ego of "Factotum" author Charles Bukowski, who wanders around Los Angeles, CA trying to live off jobs which don't interfere with his primary interest, which is writing.
After leaving Washington D.C. hospital, plastic surgeon Ben Stone heads for California, where a lucrative practice in Beverly Hills awaits.
A gas is let loose upon the world that kills anyone over 25 years old.
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