Tom the cat and Jerry the mouse get kicked out of their home and relocate to a fancy New York hotel, where a scrappy employee named Kayla will lose her job if she can’t evict Jerry before a high-class wedding at the hotel.

In 2027, in a chaotic world in which humans can no longer procreate, a former activist agrees to help transport a miraculously pregnant woman to a sanctuary at sea, where her child's birth may help scientists save the future of humankind.

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