In the future, America is a dystopian wasteland. The latest scourge is Ma-Ma, a prostitute-turned-drug pusher with a dangerous new drug and aims to take over the city.

Vampire hunter Edgar Frog is destitute and nearly friendless, when the beautiful novelist Gwen Lieber offers him a small fortune to go on a hunt to save her brother from vampires using a new drug called the Thirst, which is a mixture of Ecstasy and infected blood.

The lethal Reaper virus spreads throughout Britain—infecting millions and killing hundreds of thousands. Authorities brutally and successfully quarantine the country but, three decades later, the virus resurfaces in a major city.

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