A group of friends take refuge in a deserted sanatorium after they are left stranded in a snowstorm. Later, the place becomes a death trap when man-eating cannibals surround them.

Special Agent Strahm is dead, and Detective Hoffman has emerged as the unchallenged successor to Jigsaw's legacy. However, when the FBI draws closer to Hoffman, he is forced to set a game into motion, and Jigsaw's grand scheme is finally understood.

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