An investigation into a serial killer leads two detectives to discover that Dr. Frankenstein and his creature are still alive after two centuries of genetic experiments.

Harry Angel, a down-and-out Brooklyn detective, is hired to track down a singer on an odyssey that will take him through the desperate streets of Harlem, the smoke-filled jazz clubs of New Orleans, and the swamps of Louisiana and its seedy underworld of voodoo.

Hattie, a New Orleans prostitute, meets a photographer named Bellocq at her brothel one night and, after he photographs her, he befriends her 12-year-old daughter, Violet.

A wealthy New Orleans businessman becomes obsessed with a young woman who resembles his wife.

Warren Maxwell, the owner of a run-down plantation, pressures his son, Hammond, to marry and produce an heir to inherit the plantation.

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