A giant alligator goes head to head with a giant Anaconda. The town sheriff must find a way to destroy the two monsters before they kill the whole town.
On the trail of her missing sister, Charlotte enlists the help of Wayne, an ex-Marine and alcoholic, to infiltrate the Church of One Accord - a community of snake-handlers who risk their lives seeking salvation in the Holy Ghost.
A fanatical animal rights activist releases giant pythons into the Everglades, believing the wild animals should be set free. When they start decimating the native animal population, an over-zealous park ranger feeds experimental steroids to wild alligators so they can fight back.
After being diagnosed with brain cancer, a desperate American man kidnaps the reptilian lover of the snake goddess in hopes of gaining immortality.
A genetically created Anaconda, cut in half, regenerates itself into two new aggressive giant snakes, due to the Blood Orchid.
A mercenary-for-hire accepts a mission from a billionaire to capture a dangerous snake that could possibly help cure a terminal illness.
A set of vipers has been taken by scientists to mutate them to make a cure for cancer. As their experiment goes awry, the vipers escape into the woods - they're not only biting people, they're actually killing people, in a little town.
Duff Daniels (John T. Woods), the younger, stupider brother of Les (Michael Shanks), can't help himself from stealing a rare snake that's been kept in a jar by a Native American snake dealer (Ben Cardinal), and which has to follow some rules: don't let it out of the jar, then don't let it eat anything anything living, and never fear the heart of the snake.
FBI agent Neville Flynn boards a flight from Honolulu, Hawaii to Los Angeles, escorting a key witness to testify against a mob boss at an upcoming trial.
Under a powerful Mayan curse, snakes are hatched inside a young woman, slowly devouring her from within. Her only chance for survival is a powerful shaman who lives across the border.
A group of university students go in search of a missing friend in the jungle where they meet a giant snake.
A group of teenagers fear for their lives in the swamps of Louisiana, chased by Mr. Jangles, a man possessed by 13 evil souls, and now relentless in his pursuit of new victims.
A team of environmentalists, including a reporter, her camera man, and an environmentalist's famous girlfriend charter a boat and with the captain, sail to a military island.
An object is found that points to the secret of eternal youth so a research team is sent to find the fountain only to find it is protected by a giant snake
After an overly ambitious businessman transports an 80-foot python to the United States, the beast escapes and starts to leave behind a trail of human victims.
A scientific expedition sets out for Borneo to seek a flower called the Blood Orchid, which could grant extended life.
A man, his business partner, and his wife are enlisted to transport an unknown object from a Russian military base, only to discover that the object is a giant, genetically-altered python.
Mutant snakes survived a terrorist attack on a government laboratory, and they now threaten the town of Santa Mira Springs, California.
Paleontologist Robert Trenton is called to Northeastern Antarctica near the Indian Ocean to help the FBI build an underground maximum-security military base and prison for the world's most dangerous criminals and terrorists, which is dubbed "New Alcatrax" by the staff.

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